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Answers
Unit 8: Link and Think


  1. Strategies Against AIDS
    Prevent attachment Prevent reverse transcription Prevent integration of viral DNA Prevent production of new virus
    Treating HIV(2-5) 2 3 4 5

  2. Prevent reverse transcription of viral RNA to DNA; AZT is a reverse transcriptase inhibitor.

  3. CD4 and CCR5 (in other articles, CCR5 refered to as CKR5).

  4. CCR5. Incidentally, The Lancet, a medical journal, reported in April 1997 that a certain strain of HIV-1, the type most prevalent in North America and Europe, does not need CCR5 to infect cells. In a study of 13 people lacking CCR5, one man aquired AIDS 10 years after testing positive for HIV. This strain appears to use CXCR4, another chemokine receptor, as the co-receptor for entry into T4 cells.

  5. Treating HIV discusses CCR5, which might be blocked with chemokines.

  6. 2: HIV brings reverse transcriptase into the cell, which makes new DNA from the viral RNA template.

  7. The daughter cells of infected cells inherit the HIV genes. HIV integrates its genes into the DNA of its host cell; these genes are replicated along with the host genome every time the cell divides.

  8. 2, 3, and 4: reverse transcriptase, integrase, and protease (2, 3, and 4, respectively) are all viral enzymes targeted by enzyme inhibitors.

  9. 1: It clips viral proteins into usable pieces, smaller proteins that will assemble into new viruses.


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